trans-4-methyl-1-<<(4-methylphenyl)methyl>thio>cyclohexaneacetic acid

Base Information

• Chemical Name: trans-4-methyl-1-<<(4-methylphenyl)methyl>thio>cyclohexaneacetic acid
• CAS No.: 119326-74-8
• Molecular Formula: C₁₇H₂₄O₂S
• Molecular Weight: 292.442
• Mol file: 119326-74-8.mol

Synonyms:trans-4-methyl-1-<<(4-methylphenyl)methyl>thio>cyclohexaneacetic acid

Chemical Property of trans-4-methyl-1-<<(4-methylphenyl)methyl>thio>cyclohexaneacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of trans-4-methyl-1-<<(4-methylphenyl)methyl>thio>cyclohexaneacetic acid

There total 2 articles about trans-4-methyl-1-<<(4-methylphenyl)methyl>thio>cyclohexaneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

4-methylbenzylthiol (4498-99-1) + (4-methylcyclohexylidene)acetic acid (77842-31-0,28835-97-4,28835-95-2) → trans-4-methyl-1-<<(4-methylphenyl)methyl>thio>cyclohexaneacetic acid (119326-74-8)

Guidance literature:

With piperidine; In toluene; for 18h; Heating;

DOI:10.1021/jm00124a025

Reference yield:

ethyl 4-methylcyclohexylideneacetate (127180-76-1,42778-89-2,191113-70-9) → trans-4-methyl-1-<<(4-methylphenyl)methyl>thio>cyclohexaneacetic acid (119326-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / aq. K₂CO₃ / methanol / 18 h / Heating

2: 29 percent / piperidine / toluene / 18 h / Heating

With piperidine; potassium carbonate; In methanol; toluene;

DOI:10.1021/jm00124a025

upstream raw materials:

4-methylbenzylthiol

(4-methylcyclohexylidene)acetic acid

ethyl 4-methylcyclohexylideneacetate