5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

Base Information

Chemical Name:5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate
CAS No.:252960-93-3
Molecular Formula:C₂₅H₂₈N₄O₄
Molecular Weight:448.522
Hs Code.:

Synonyms:5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

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Chemical Property of 5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

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Technology Process of 5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

There total 8 articles about 5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 252960-92-2
Benzyl 5-[2-(1-benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

: 252960-93-3
5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 48h;
DOI:10.1039/a903141c

Reference yield:

: 139973-76-5,191864-28-5
DL-4-(4-nitrophenyl)-2-aminobutanoic acid

: 252960-93-3
5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 20 percent / KOH / H₂O / 2 h / 60 - 70 °C

2.1: HCl / H₂O / 2 h / Heating

3.1: 85 percent / H₂; HCl / 10 percent Pd/C / aq. ethanol / 20 °C

4.1: NaNO₂; HCl / aq. ethanol / 0.17 h / 0 °C

4.2: 26 percent / AcONa*3H₂O / aq. ethanol / 5 h / 20 °C

5.1: 58 percent / HCl / aq. ethanol / 24 h / Heating

6.1: 60 percent / (i-PrO)4Ti / 18 h / 100 °C

7.1: 95 percent / H₂ / 10 percent Pd/C / ethanol / 48 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; potassium hydroxide; hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol; water; 1.1: Acylation / 2.1: Cyclization / 3.1: Catalytic hydrogenation / 4.1: Diazotization / 4.2: Condensation / 5.1: Cyclization / 6.1: Transesterification / 7.1: Catalytic hydrogenation;
DOI:10.1039/a903141c

Reference yield:

: 3173-56-6
benzyl isothiocyanate

: 252960-93-3
5-[2-(1-Benzyl-2,5-dioxoimidazolidin-4-yl)ethyl]-3-[2-(dimethylamino)ethyl]-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 20 percent / KOH / H₂O / 2 h / 60 - 70 °C

2.1: HCl / H₂O / 2 h / Heating

3.1: 85 percent / H₂; HCl / 10 percent Pd/C / aq. ethanol / 20 °C

4.1: NaNO₂; HCl / aq. ethanol / 0.17 h / 0 °C

4.2: 26 percent / AcONa*3H₂O / aq. ethanol / 5 h / 20 °C

5.1: 58 percent / HCl / aq. ethanol / 24 h / Heating

6.1: 60 percent / (i-PrO)4Ti / 18 h / 100 °C

7.1: 95 percent / H₂ / 10 percent Pd/C / ethanol / 48 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; potassium hydroxide; hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol; water; 1.1: Acylation / 2.1: Cyclization / 3.1: Catalytic hydrogenation / 4.1: Diazotization / 4.2: Condensation / 5.1: Cyclization / 6.1: Transesterification / 7.1: Catalytic hydrogenation;
DOI:10.1039/a903141c