methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate

Base Information

• Chemical Name: methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate
• CAS No.: 113707-58-7
• Molecular Formula: C₂₆H₃₂N₂O₃
• Molecular Weight: 420.552
• Mol file: 113707-58-7.mol

Synonyms:methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate

Chemical Property of methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate

There total 4 articles about methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate (113707-63-4) → methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate (113707-58-7)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; chloroform; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)81658-6

Reference yield:

bromoethyl-2-benzyl ether (1462-37-9) → methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate (113707-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / 5 h / 95 - 100 °C

2: 77 percent / H₂ / PtO₂ / methanol; CHCl₃ / 760 Torr / Ambient temperature

With hydrogen; platinum(IV) oxide; In methanol; chloroform;

DOI:10.1016/S0040-4020(01)81658-6

Reference yield:

methyl 1-methyl-α-(4-pyridylmethyl)-2-indoleacetate (113707-57-6) → methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate (113707-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / 5 h / 95 - 100 °C

2: 77 percent / H₂ / PtO₂ / methanol; CHCl₃ / 760 Torr / Ambient temperature

With hydrogen; platinum(IV) oxide; In methanol; chloroform;

DOI:10.1016/S0040-4020(01)81658-6

upstream raw materials:

methyl α<1-<2-(benzyloxy)ethyl>-4-piperidyl>-1-methyl-2-indoleacetate

bromoethyl-2-benzyl ether

methyl 1-methyl-α-(4-pyridylmethyl)-2-indoleacetate

1-methyl-2-(4-pyridylmethyl)indole

Downstream raw materials:

methyl 2,7-dimethyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole-6-carboxylate

methyl 2-<2-(benzyloxy)ethyl>-7-methyl-1,2,3,4,5,6-hexahydro-1,5-methanoazocino<4,3-b>indole-6-carboxylate