4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine

Base Information

Chemical Name:4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine
CAS No.:886228-75-7
Molecular Formula:C₂₀H₃₂FNO₂Si
Molecular Weight:365.563
Hs Code.:

4-[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine

Synonyms:4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine

Chemical Property:

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Technology Process of 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine

There total 6 articles about 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1010396-60-7
methyl (Z)-4-(bromomethyl)-3-(4-fluorophenyl)-2-propenoate

: 886228-75-7
4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / acetonitrile / Heating

2: aq. HCl / methanol

3: 100 percent / imidazole / dimethylformamide

4: 86 percent / DIBAL-H / CH₂Cl₂

5: Et₃N / CH₂Cl₂ / 0 °C

6: CH₂Cl₂

With 1H-imidazole; hydrogenchloride; diisobutylaluminium hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-2006-932489

Reference yield:

: 3-(4-fluoro-phenyl)-2-formyloxymethyl-acrylic acid methyl ester

: 886228-75-7
4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine

Guidance literature:: Multi-step reaction with 5 steps

1: aq. HCl / methanol

2: 100 percent / imidazole / dimethylformamide

3: 86 percent / DIBAL-H / CH₂Cl₂

4: Et₃N / CH₂Cl₂ / 0 °C

5: CH₂Cl₂

With 1H-imidazole; hydrogenchloride; diisobutylaluminium hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-932489

Reference yield:

: 886228-59-7
3-(4-fluoro-phenyl)-2-hydroxymethyl-acrylic acid methyl ester

: 886228-75-7
4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-allyl]-morpholine

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / imidazole / dimethylformamide

2: 86 percent / DIBAL-H / CH₂Cl₂

3: Et₃N / CH₂Cl₂ / 0 °C

4: CH₂Cl₂

With 1H-imidazole; diisobutylaluminium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-932489