[(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol

Base Information

Chemical Name:[(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol
CAS No.:270925-65-0
Molecular Formula:C₂₆H₃₀N₂O₃Si
Molecular Weight:446.621
Hs Code.:

Synonyms:[(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol

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Chemical Property of [(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol

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Technology Process of [(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol

There total 2 articles about [(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20511-12-0
2-amino-5-iodopyridine

: 130277-32-6
((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol

: 270925-65-0
[(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; tris(pentafluorophenyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; at 95 ℃; for 30h;
DOI:10.1021/ja020639y

Reference yield:

: 504-29-0
2-aminopyridine

: 270925-65-0
[(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / I₂; periodic acid dihydrate; H₂SO₄ / acetic acid; H₂O / 4 h / 80 °C

2: bis(dibenzylideneacetone)palladium⁽⁰⁾; tris(pentafluorophenyl)phosphine; N,N-diisopropylethylamine / acetonitrile / 30 h / 95 °C

With sulfuric acid; iodine; periodic acid; N-ethyl-N,N-diisopropylamine; tris(pentafluorophenyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; acetic acid; acetonitrile; 2: Heck reaction;
DOI:10.1021/ja020639y

Reference yield:

: 270925-65-0
[(2R,5R)-5-(6-Amino-pyridin-3-yl)-3-(tert-butyl-diphenyl-silanyloxy)-2,5-dihydro-furan-2-yl]-methanol

: 460984-29-6
5-(β-D-glyceropentafuran-3'-ulos-1'-yl)-2-aminopyridine p-toluensulfonyl-hydrazone

Guidance literature:: Multi-step reaction with 2 steps

1: 0.74 g / tetra-n-butyl-ammonium fluoride; acetic acid / tetrahydrofuran / 0.67 h

2: 97 percent / methanol / 20 °C

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/ja020639y