methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

Base Information

Chemical Name:methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate
CAS No.:160557-08-4
Molecular Formula:C₃₂H₄₀N₄O₆
Molecular Weight:576.693
Hs Code.:

Synonyms:methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

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Chemical Property of methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

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Technology Process of methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

There total 10 articles about methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 24424-99-5
di-tert-butyl dicarbonate

: methyl <4(5)R>-2-<(1RS)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-4,5-dihydroimidazole-4(5)-carboxylate

: 160557-09-5
methyl <4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

: 160557-08-4
methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; for 3h; Ambient temperature;
DOI:10.1016/0040-4020(95)00273-B

Reference yield:

: 327-56-0
D-norleucine

: 160557-08-4
methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / 1 M aq. NaOH / ethanol

2: 56 percent / CH₂Cl₂ / -20 °C

3: 1.) LiN(SiMe₃)2 / 1.) THF, from -78 to -65 deg C, 2.) THF

4: 75 percent / AcCl / 16 h / Heating

5: 1.) MeI / 1.) reflux, 16 h, 2.) MeOH, reflux, 16 h

6: aq. NaHCO₃ / tetrahydrofuran

With sodium hydroxide; sodium hydrogencarbonate; acetyl chloride; lithium hexamethyldisilazane; methyl iodide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/0957-4166(94)80075-8

Reference yield:

: 160637-54-7
methyl (R)-2-aminomethylhexanoate

: 160557-08-4
methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) MeI / 1.) reflux, 16 h, 2.) MeOH, reflux, 16 h

2: aq. NaHCO₃ / tetrahydrofuran

With sodium hydrogencarbonate; methyl iodide; In tetrahydrofuran;
DOI:10.1016/0957-4166(94)80075-8