2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate

Base Information

Chemical Name:2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate
CAS No.:1010115-41-9
Molecular Formula:C₂HF₃O₂*C₁₈H₂₂N₂O₃S
Molecular Weight:460.474
Hs Code.:

Synonyms:2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate

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Chemical Property of 2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate

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Technology Process of 2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate

There total 1 articles about 2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1010113-01-5
tert-butyl 4-((6-(4-(methylsulfonyl)phenyl)pyridine-3-yloxy)methyl)piperidin-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1010115-41-9
2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate

Guidance literature:: tert-butyl 4-((6-(4-(methylsulfonyl)phenyl)pyridine-3-yloxy)methyl)piperidin-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

trifluoroacetic acid; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield: 19.0%

: 1032825-79-8
5-bromo-3-(1-methylethyl)-1,2,4-thiadiazole

: 1010115-41-9
2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate

: 76-05-1
trifluoroacetic acid

: 1032824-69-3
5-[({1-[3-(1-Methylethyl)-1,2,4-thiadiazol-5-yl]-4-piperidinyl}methyl)oxy]-2-[4-(methylsulfonyl)phenyl]pyridine trifluoroacetate

Guidance literature:: 5-bromo-3-(1-methylethyl)-1,2,4-thiadiazole; 2-[4-(methylsulfonyl)phenyl]-5-[(4-piperidinylmethyl)oxy]pyridine trifluoroacetate; With triethylamine; In 1,2-dichloro-ethane; for 2h; Reflux;

trifluoroacetic acid; In water; acetonitrile;