4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl

Base Information

Chemical Name:4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl
CAS No.:1142228-30-5
Molecular Formula:C₂₁H₂₀ClF₃
Molecular Weight:364.838
Hs Code.:

Synonyms:4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl

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Chemical Property of 4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl

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Technology Process of 4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl

There total 13 articles about 4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1142228-27-0
(5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol

: 1142228-30-5
4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1011531-89-7
2-(5,5-dimethylcyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1 ,3 ,2-dioxaborolane

: 1142228-30-5
4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / methanol / 19 h / 50 °C

3.1: dmap; triethylamine / dichloromethane / 0.33 h

3.2: 3 h / 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 19 h / 23 - 90 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

6.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

With dmap; potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 4541-32-6
2,2-dimethylcyclopentanone

: 1142228-30-5
4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / -78 °C

1.2: 18 h / -78 - 20 °C

2.1: potassium phenolate / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / toluene / 2 h / 50 °C / Inert atmosphere

3.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / methanol / 19 h / 50 °C

5.1: dmap; triethylamine / dichloromethane / 0.33 h

5.2: 3 h / 20 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 19 h / 23 - 90 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

8.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

With dmap; potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; potassium phenolate; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; toluene;