N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide

Base Information

Chemical Name:N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide
CAS No.:1402581-31-0
Molecular Formula:C₂₂H₂₁ClF₃N₃O₃
Molecular Weight:467.875
Hs Code.:

Synonyms:N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide

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Chemical Property of N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide

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Technology Process of N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide

There total 15 articles about N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1402585-32-3
C₂₃H₂₁ClF₃N₃O₄

: 1402581-31-0
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

: 1402586-55-3
C₁₄H₁₄ClN₃

: 1402581-31-0
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 23 °C

3: ethanol; sodium hydroxide / 6 h / 80 °C

4: thionyl chloride / 24 h / 0 - 35 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

With lithium aluminium tetrahydride; thionyl chloride; ethanol; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 1254713-79-5
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

: 1402581-31-0
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[4-(hydroxymethyl)-3-methoxyphenyl]propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 23 °C

2: ethanol; sodium hydroxide / 6 h / 80 °C

3: thionyl chloride / 24 h / 0 - 35 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

With lithium aluminium tetrahydride; thionyl chloride; ethanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; acetonitrile;