Technology Process of (2S,5S)-dibenzhydryl 7'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate
There total 2 articles about (2S,5S)-dibenzhydryl 7'-chloro-1'-methyl-2'-oxo-5-vinyl-4,5-dihydro-3H-spiro[furan-2,3'-indoline]-3,3-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); (4R,5R)-2-((S)-1-(2-(dibutylphosphino)naphthalen-1-yl)naphthalen-2-yl)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazole; lithium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 48h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/om400473p
- Guidance literature:
-
Multi-step reaction with 2 steps
1: caesium carbonate / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere; Schlenk technique
2: (4R,5R)-2-((S)-1-(2-(dibutylphosphino)naphthalen-1-yl)naphthalen-2-yl)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazole; tris-(dibenzylideneacetone)dipalladium(0); lithium chloride / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere; Schlenk technique
With
tris-(dibenzylideneacetone)dipalladium(0); (4R,5R)-2-((S)-1-(2-(dibutylphosphino)naphthalen-1-yl)naphthalen-2-yl)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazole; caesium carbonate; lithium chloride;
In
tetrahydrofuran;
DOI:10.1021/om400473p
