2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one

Base Information

Chemical Name:2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one
CAS No.:1299467-24-5
Molecular Formula:C₂₃H₁₉F₃N₂O₄
Molecular Weight:444.41
Hs Code.:

Synonyms:2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one

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Chemical Property of 2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one

Chemical Property:

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Technology Process of 2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one

There total 5 articles about 2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[N'-tert-butoxycarbonyl-N'-((R)-2,2-dimethyl[1,3]dioxolan-4-ylmethyl)hydrazino]-3-(2',4',5'-trifluorobiphenyl-4-yloxymethyl)benzoic acid methyl ester

: 1299467-24-5
2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; for 1.5h; Reflux;
DOI:10.1016/j.bmcl.2013.03.049

Reference yield:

: 750585-90-1
methyl 2-bromo-3-(bromomethyl)benzoate

: 1299467-24-5
2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 6 h / 50 °C

2: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 5 h / 120 °C / Inert atmosphere; Sealed

3: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate; In tetrahydrofuran; water; acetone; toluene;

Reference yield:

: 131001-86-0
methyl 2-bromo-3-methylbenzoate

: 1299467-24-5
2-((R)-2,3-dihydroxy-propyl)-7-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-1,2-dihydro-indazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / V₆₅ catalyst / dichloromethane / 15 h / 42 °C

2: potassium carbonate / acetone / 6 h / 50 °C

3: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 5 h / 120 °C / Inert atmosphere; Sealed

4: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate; In tetrahydrofuran; dichloromethane; water; acetone; toluene;