4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
CAS No.:161462-85-7
Molecular Formula:C₂₅H₂₄N₂O₇
Molecular Weight:464.475
Hs Code.:

Synonyms:4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of 4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Technology Process of 4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 1 articles about 4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 65-71-4,28806-14-6,691841-57-3
thymin

: 4-Methyl-benzoic acid (2S,4R)-4,5-bis-benzoyloxy-tetrahydro-furan-2-ylmethyl ester

: 161462-85-7
4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 70 ℃;
DOI:10.1016/S0040-4039(00)78530-3

Reference yield: 81.0%

: 161462-85-7
4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 156737-16-5
4-Methyl-benzoic acid (2S,4R,5R)-4-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With sodium methylate; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4039(00)78530-3

Reference yield:

: 161462-85-7
4-Methyl-benzoic acid (2S,4R,5R)-4-benzoyloxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: C₄₂H₄₇N₄O₁₄P*C₆H₁₅N

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / MeONa / tetrahydrofuran / Ambient temperature

2: 67 percent / benzoyl peroxide / acetonitrile / 0 °C

3: 1.) Br₂, 2,6-lutidine; 2.) NH₃ / 1.) CH₂Cl₂, PhH, from 0 degC to room t.; 2.) MeOH, 60 degC

4: 83 percent / pyridine / Ambient temperature

5: 80 percent / tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

6: 1.) 2-chloro-4H-1,2,3-benzodioxaphosphorin-4-one / 1.) CH₂Cl₂/Pyr, 0 degC; 2.) water

With 2,6-dimethylpyridine; 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; tetrabutyl ammonium fluoride; ammonia; bromine; sodium methylate; dibenzoyl peroxide; In tetrahydrofuran; pyridine; acetonitrile;
DOI:10.1016/S0040-4039(00)78530-3