((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate

Base Information

Chemical Name:((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate
CAS No.:1262486-49-6
Molecular Formula:C₃₄H₂₉Cl₂N₅O₇
Molecular Weight:690.54
Hs Code.:

((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate

Synonyms:((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate

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Chemical Property of ((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate

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Technology Process of ((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate

There total 6 articles about ((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1262486-45-2
2-ethynyl-6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazine

: (2R,3S,5R)-5-azido-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate

: 1262486-49-6
((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate

Guidance literature:: With copper; copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; water; isopropyl alcohol; at 90 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1021/jo102089h

Reference yield:

: 1205677-55-9
2-chloro-6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazine

: 1262486-49-6
((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; tetra-(n-butyl)ammonium iodide; triethylamine / N,N-dimethyl-formamide / 0.33 h / 80 °C / Microwave irradiation

1.2: 20 °C

2.1: copper; copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / tetrahydrofuran; water; isopropyl alcohol / 0.33 h / 90 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide; copper; copper(II) sulfate; triethylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; 1.1: Sonogashira coupling;
DOI:10.1021/jo102089h

Reference yield:

: 1262486-28-1
1-(4-methoxybenzyl)-5-chloro-3-methoxy-6-methylpyrazine-2(1H)-thione

: 1262486-49-6
((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(6-methoxy-5-(4-methoxyphenyl)-3-methylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine / dichloromethane / 0.25 h / 80 °C / Microwave irradiation

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate / tetrahydrofuran / 1 h / 120 °C / Microwave irradiation

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; tetra-(n-butyl)ammonium iodide; triethylamine / N,N-dimethyl-formamide / 0.33 h / 80 °C / Microwave irradiation

3.2: 20 °C

4.1: copper; copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / tetrahydrofuran; water; isopropyl alcohol / 0.33 h / 90 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; iodine; tetra-(n-butyl)ammonium iodide; copper; copper(II) sulfate; triethylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: Liebeskind-Srogl coupling / 3.1: Sonogashira coupling;
DOI:10.1021/jo102089h