(1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine

Base Information

Chemical Name:(1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine
CAS No.:133299-33-9
Molecular Formula:C₂₉H₃₅N₅O₅
Molecular Weight:533.627
Hs Code.:

Synonyms:(1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine

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Chemical Property of (1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine

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Technology Process of (1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine

There total 6 articles about (1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 133299-32-8
(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate

: 133299-33-9
(1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 100 ℃; for 1h;
DOI:10.1039/P19910002479

Reference yield:

: 105797-60-2
2-amino-6-(2-methoxyethoxy)purine

: 133299-33-9
(1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 1) lithium hydride / 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h

2: 90 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.75 h

3: 79 percent / Bu₃SnH, azoisobutyronitrile / toluene / 1 h / 100 °C

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium hydride; In dichloromethane; toluene;
DOI:10.1039/P19910002479

Reference yield:

: 117641-39-1
(2R,3S)-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexan-3-ol

: 133299-33-9
(1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaH, 2) tetrabutylammonium iodide / 1) THF, r.t., 1 h, 2) DMF, reflux, 1.5 h

2: 1) lithium hydride / 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h

3: 90 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.75 h

4: 79 percent / Bu₃SnH, azoisobutyronitrile / toluene / 1 h / 100 °C

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; lithium hydride; sodium hydride; In dichloromethane; toluene;
DOI:10.1039/P19910002479