(S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Chemical Name:(S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester
CAS No.:1163792-41-3
Molecular Formula:C₃₁H₄₁N₅O₈
Molecular Weight:611.695
Hs Code.:

(S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester

Synonyms:(S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Chemical Property of (S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Technology Process of (S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester

There total 6 articles about (S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1163792-11-7
5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carboxylic acid

: 6234-01-1,16948-36-0
L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride

: 1163792-41-3
(S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;
DOI:10.1021/jm300771j

Reference yield:

: 27241-29-8
5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1163792-41-3
(S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 2250.23 Torr

3.1: benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h

4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C / 2250.23 Torr / Enzymatic reaction

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h

5.2: 0.5 h

6.1: sodium hydroxide / tetrahydrofuran; water / 4 h / 0 °C

7.1: benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; caesium carbonate; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm300771j

Reference yield:

: 1163792-07-1
5-carboxymethoxy-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1163792-41-3
(S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}amino)pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C / 2250.23 Torr / Enzymatic reaction

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h

3.2: 0.5 h

4.1: sodium hydroxide / tetrahydrofuran; water / 4 h / 0 °C

5.1: benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm300771j