5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester
• CAS No.: 956413-43-7
• Molecular Formula: C₄₅H₅₇BrN₄O₁₀Si
• Molecular Weight: 921.958
• Mol file: 956413-43-7.mol

Synonyms:5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester

Chemical Property of 5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester

There total 1 articles about 5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H22BrN3O6 (956413-41-5) + 2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionic acid (956413-42-6) → 5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester (956413-43-7)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ja0744448

Reference yield: 67.0%

5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester (956413-43-7) → 5-(7-bromo-3-chloro-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester (956413-45-9)

Guidance literature:

With 2,4,6-trimethyl-pyridine; thionyl chloride; In diethyl ether; at -78 ℃; for 0.166667h;

DOI:10.1021/ja0744448

upstream raw materials:

C₁₉H₂₂BrN₃O₆

2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionic acid

Downstream raw materials:

5-(7-bromo-3-chloro-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-{1-[2-benzyloxycarbonylamino-3-(4-triisopropylsilanyloxyphenyl)propionylamino]-2-methylpropyl}oxazole-4-carboxylic acid methyl ester