3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile

Base Information

Chemical Name:3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile
CAS No.:1600566-65-1
Molecular Formula:C₂₉H₂₁F₄N₅O₂
Molecular Weight:547.512
Hs Code.:

Synonyms:3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile

Suppliers and Price of 3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile

There total 10 articles about 3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1600566-59-3
(4-chloro-3-(3-fluorophenyl)-2-methoxy-8-methylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

: 1600566-65-1
3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos; In N,N-dimethyl acetamide; at 120 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1121-86-4
1-Fluoro-3-iodobenzene

: 1600566-65-1
3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; copper(l) iodide / 1,4-dioxane / 20 °C / Inert atmosphere

2.1: sodium hydroxide / water / 0.17 h / 65 °C

3.1: trichlorophosphate / 1 h / 70 °C

3.2: 3 h / 105 °C

4.1: toluene / 24 h / 100 °C / Sealed tube

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos / N,N-dimethyl acetamide / 4 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; n-butyllithium; caesium carbonate; sodium hydroxide; zinc; XPhos; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl acetamide; water; toluene;

Reference yield:

: diethyl 2-(3-fluorophenyl)malonate

: 1600566-65-1
3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methoxy-8-methylquinoline-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water / 0.17 h / 65 °C

2.1: trichlorophosphate / 1 h / 70 °C

2.2: 3 h / 105 °C

3.1: toluene / 24 h / 100 °C / Sealed tube

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos / N,N-dimethyl acetamide / 4 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; sodium hydroxide; zinc; XPhos; trichlorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; water; toluene;