N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine

Base Information

Chemical Name:N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine
CAS No.:126411-06-1
Molecular Formula:C₃₅H₅₄N₂O₆Si
Molecular Weight:626.909
Hs Code.:

Synonyms:N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine

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Chemical Property of N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine

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Technology Process of N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine

There total 3 articles about N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 135832-58-5
N-{5(S)-[(tert-butoxycarbonyl)amino]-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl}valine methyl ester

: 126411-06-1
N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine

Guidance literature:: With lithium hydroxide; In 1,2-dimethoxyethane; for 1h; Ambient temperature;
DOI:10.1021/jm00113a025

Reference yield:

: 6306-52-1
L-valine methylester hydrochloride

: 126411-06-1
N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC), triethylamine / dimethylformamide / 18 h / Ambient temperature

2: 100 percent / LiOH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a025

Reference yield:

: 98818-51-0
N-(1,1-dimethylethoxycarbonyl)-5(S)-amino-4(S)-(t-butyldimethylsilyloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoic acid

: 126411-06-1
N-<5(S)-<(tert-butoxycarbonyl)amino>-4(S)-(tert-butyldimethylsiloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoyl>valine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC), triethylamine / dimethylformamide / 18 h / Ambient temperature

2: 100 percent / LiOH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a025