2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

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Chemical Name:2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester
CAS No.:229160-30-9
Molecular Formula:C₆₃H₇₄N₂O₁₈S
Molecular Weight:1179.35
Hs Code.:

2-[2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-<i>tert</i>-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

Synonyms:2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

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Chemical Property of 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

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Technology Process of 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

There total 1 articles about 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223480-03-3
methyl-6-O-carboxy-(N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-α-tert-butyl ester)-α-D-manno-pyranoside

: 229160-30-9
2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / dimethylformamide / 0.5 h

2: EEDQ / benzene; ethanol / 15 h

With piperidine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In ethanol; N,N-dimethyl-formamide; benzene; 1: aminolysis / 2: Condensation;
DOI:10.1016/S0957-4166(99)00494-2

Reference yield: 13.0%

: 229160-30-9
2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

: (1S,3S,4S,5S,6R,7R,12S,15S,20R,22S,23S,24S)-4,5,6-Tris-benzyloxy-12-(9H-fluoren-9-ylmethoxycarbonylamino)-23,24-dihydroxy-22-methoxy-10,13,17-trioxo-2,9,18,21,25-pentaoxa-14-aza-tricyclo[18.2.2.1^3,7]pentacosane-15-carboxylic acid tert-butyl ester

: (1R,3S,4S,5S,7R,12S,15S,20R,21R,22S,23S,25R)-21,22,23-Tris-benzyloxy-15-(9H-fluoren-9-ylmethoxycarbonylamino)-4,25-dihydroxy-5-methoxy-10,14,17-trioxo-2,6,9,18,24-pentaoxa-13-aza-tricyclo[18.3.1.1^3,7]pentacosane-12-carboxylic acid tert-butyl ester

: (1S,3S,4S,5S,7R,12S,15S,20R,21R,22S,23S,25R)-21,22,23-Tris-benzyloxy-15-(9H-fluoren-9-ylmethoxycarbonylamino)-4,25-dihydroxy-5-methoxy-10,14,17-trioxo-2,6,9,18,24-pentaoxa-13-aza-tricyclo[18.3.1.1^3,7]pentacosane-12-carboxylic acid tert-butyl ester

Guidance literature:: With N-iodo-succinimide; trifluorormethanesulfonic acid; In dichloromethane; at -40 ℃;
DOI:10.1039/a901916b

Reference yield: 11.0%

: 229160-30-9
2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

: (2R,3R,4S,5S,6S)-2-Hydroxymethyl-6-methoxy-4-((2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3,5-diol

: (2R,3R,4S,5S,6S)-2-Hydroxymethyl-6-methoxy-4-((2S,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3,5-diol

: (2R,3S,4S,5S,6S)-2-Hydroxymethyl-6-methoxy-5-((2S,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3,4-diol

Guidance literature:: 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-tris-benzyloxy-6-ethylsulfanyl-tetrahydro-pyran-2-ylmethoxycarbonyl)-propionylamino]-succinic acid 1-tert-butyl ester 4-(3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester; With N-iodo-succinimide; trifluorormethanesulfonic acid; In dichloromethane; at -40 ℃; for 0.0833333h;

With methanol; potassium carbonate; for 0.5h;
DOI:10.1016/S0957-4166(99)00494-2