N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

Base Information

Chemical Name:N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide
CAS No.:1370035-06-5
Molecular Formula:C₂₇H₂₄N₄O₃S
Molecular Weight:484.579
Hs Code.:

Synonyms:N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

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Chemical Property of N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

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Technology Process of N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

There total 9 articles about N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 2759-28-6
1-phenylmethylpiperazine

: 1370035-04-3
2-benzoylamino-4-oxo-4H-3,1-benzothiazine-6-carboxylic acid

: 1370035-06-5
N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

Guidance literature:: 2-benzoylamino-4-oxo-4H-3,1-benzothiazine-6-carboxylic acid; With 1,1'-carbonyldiimidazole; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

1-phenylmethylpiperazine; With 1H-imidazole; hydrogenchloride; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm300029s

Reference yield:

: 4315-09-7
4-nitroisophthalic acid

: 1370035-06-5
N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h

2.1: pyridine; zinc(II) chloride / 12 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / Inert atmosphere

4.1: acetonitrile / 3 h / 20 °C

5.1: sulfuric acid / 48 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / 1,4-dioxane; N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 2 h / 20 °C

With pyridine; oxalyl dichloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; zinc(II) chloride; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300029s

Reference yield:

: 532-55-8
Benzoyl isothiocyanate

: 1370035-06-5
N-(6-(4-benzylpiperazine-1-carbonyl)-4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 3 h / 20 °C

2.1: sulfuric acid / 48 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / 1,4-dioxane; N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 2 h / 20 °C

With sulfuric acid; 1,1'-carbonyldiimidazole; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300029s