1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine

Base Information

Chemical Name:1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine
CAS No.:1427587-96-9
Molecular Formula:C₂₄H₂₈ClN₅O
Molecular Weight:437.972
Hs Code.:

Synonyms:1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine

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Chemical Property of 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine

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Technology Process of 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine

There total 6 articles about 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1334711-86-2
4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine

: 55112-42-0
4-methylpiperazine-1-carbonyl chloride monohydrochloride

: 1427587-96-9
1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

Reference yield:

: 921196-57-8
tert-butyl 4-{1H-pyrrolo[2,3-c]pyridin-3-yl}-1,2,3,6-tetrahydropyridine-1-carboxylate

: 1427587-96-9
1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 90 °C / 67506.8 Torr

2: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 0.33 h / 160 °C / Inert atmosphere; Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 2 h

4: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 18 h

With dmap; potassium phosphate; copper(l) iodide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N,N`-dimethylethylenediamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 271-29-4
6-azaindole

: 1427587-96-9
1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / methanol / 18 h / 70 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 90 °C / 67506.8 Torr

3: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 0.33 h / 160 °C / Inert atmosphere; Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 2 h

5: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 18 h

With dmap; potassium phosphate; copper(l) iodide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; N,N`-dimethylethylenediamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;