C₁₃H₁₄F₃NO

Base Information

• Chemical Name: C₁₃H₁₄F₃NO
• CAS No.: 1356856-72-8
• Molecular Formula: C₁₃H₁₄F₃NO
• Molecular Weight: 257.255
• Mol file: 1356856-72-8.mol

Synonyms:C₁₃H₁₄F₃NO

Chemical Property of C₁₃H₁₄F₃NO

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₃H₁₄F₃NO

There total 1 articles about C₁₃H₁₄F₃NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-(trifluromethyl)acetanilide (349-97-3) + but-3-enyl 4-methylbenzenesulfonate (778-29-0) → C13H14F3NO (1356856-72-8)

Guidance literature:

4-(trifluromethyl)acetanilide; With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; In toluene; at 80 ℃; for 0.25h; Inert atmosphere;

but-3-enyl 4-methylbenzenesulfonate; In toluene; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201106162

Reference yield: 58.0%

C13H14F3NO (1356856-72-8) → 1-methyl-2-(4-(trifluoromethyl)phenyl)-2-azabicyclo[3.1.0]hexane

Guidance literature:

With titanium(IV) isopropylate; cyclopentylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201106162

Reference yield:

C13H14F3NO (1356856-72-8) → C21H22F3N + C21H22F3N

Guidance literature:

Multi-step reaction with 2 steps

1: titanium(IV) isopropylate; cyclopentylmagnesium chloride / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere

2: Ru(bpz)₃(PF₆)_2*2H₂O / nitromethane / 36 h / 20 °C / Inert atmosphere; Irradiation

With titanium(IV) isopropylate; Ru(bpz)₃(PF₆)_2*2H₂O; cyclopentylmagnesium chloride; In tetrahydrofuran; diethyl ether; nitromethane;

DOI:10.1002/anie.201106162

upstream raw materials:

4-(trifluromethyl)acetanilide

but-3-enyl 4-methylbenzenesulfonate