N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Base Information

Chemical Name:N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
CAS No.:646066-35-5
Molecular Formula:C₃₂H₃₅N₃O₄Si
Molecular Weight:553.733
Hs Code.:

<i>N</i>-{1-[2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Synonyms:N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Chemical Property of N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Technology Process of N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

There total 3 articles about N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 26661-13-2
4-N-benzoylcytosine

: 646066-33-3
acetic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl ester

: 646066-35-5
N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 20h;
DOI:10.1016/j.tet.2003.09.093

Reference yield:

: 646066-29-7
2-[(tert-butyl(diphenyl)silyloxy)methyl]acrylic acid ethyl ester

: 646066-35-5
N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / DIBAL-H / toluene / 3 h / -70 °C

2: 88 percent / lithium bromide; p-toluenesulfonic acid / 18 h / 20 °C

3: 58 percent / H₂SO₄ / 0 - 5 °C

4: 64 percent / TMSOTf; BSA / acetonitrile / 20 h / 20 °C

With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; diisobutylaluminium hydride; toluene-4-sulfonic acid; lithium bromide; In toluene; acetonitrile;
DOI:10.1016/j.tet.2003.09.093

Reference yield:

: 646066-32-2
tert-butyldiphenylsilyl 2-(methoxymethoxymethyl)-prop-2-enyl ether

: 646066-35-5
N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-allyloxymethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / H₂SO₄ / 0 - 5 °C

2: 64 percent / TMSOTf; BSA / acetonitrile / 20 h / 20 °C

With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; In acetonitrile;
DOI:10.1016/j.tet.2003.09.093