(6-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (6-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 855784-40-6
• Molecular Formula: C11H16 N2 O3
• Molecular Weight: 224.26
• Hs Code.: 2933399090
• Mol file: 855784-40-6.mol

Synonyms:(6-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property of (6-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.00514mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 275.3°C at 760 mmHg
• PKA: 12.10±0.70(Predicted)
• Flash Point: 120.3°C
• PSA: 60.45000
• Density: 1.146g/cm³
• LogP: 2.51020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(6-Methoxy-pyridin-2-yl)-carbamic acid tert-butyl ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 1 articles about (6-METHOXY-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-6-methoxypyridine (17920-35-3) + di-tert-butyl dicarbonate (24424-99-5) → C11H16N2O3 (855784-40-6)

Guidance literature:

2-amino-6-methoxypyridine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -15 ℃; for 0.5h; Inert atmosphere;

di-tert-butyl dicarbonate; In tetrahydrofuran; at -15 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.6b04966

Reference yield:

C11H16N2O3 (855784-40-6) → methyl 2-(2-((tert-butoxycarbonyl)((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)amino)-6-methoxypyridin-4-yl)benzoate

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: norborn-2-ene; silver(I) acetate; palladium diacetate; N-(2-hydroxypyridin-3-yl)acetamide / 1,2-dichloro-ethane / 24 h / 100 °C

With norborn-2-ene; N-(2-hydroxypyridin-3-yl)acetamide; silver(I) acetate; palladium diacetate; sodium hydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jacs.6b04966

upstream raw materials:

2-amino-6-methoxypyridine

di-tert-butyl dicarbonate

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