4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide

Base Information

Chemical Name:4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide
CAS No.:908609-70-1
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

4-(3,3-dimethyl-oxiranylmethyl)-<i>N</i>,<i>N</i>-diethyl-3-hydroxy-5-methoxy-benzamide

Synonyms:4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide

Chemical Property:

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Technology Process of 4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide

There total 11 articles about 4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 908609-69-8
4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-methoxy-5-triisopropylsilanyloxy-benzamide

: 908609-70-1
4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 1h;
DOI:10.1055/s-2006-941561

Reference yield:

: 908609-54-1
N,N-diethyl 3-hydroxy-5-methoxybenzamide

: 908609-70-1
4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: SO₂Cl₂; s-collidine / CH₂Cl₂ / 0.2 h / -78 °C

1.2: Et₃N / CH₂Cl₂ / 5 h / -78 - 0 °C

2.1: 98 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: 90 percent / NaBH₄ / CH₂Cl₂ / 2 h / Heating

4.1: 90 percent / H₂ / Raney Ni T-4 / ethanol / 0.5 h / 20 °C

5.1: pyridine / 3 h / 20 °C

6.1: K₂CO₃ / 1 h / 20 °C

7.1: 90 percent / Sc(OTf)3 / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 2,4,6-trimethyl-pyridine; sodium tetrahydroborate; sulfuryl dichloride; hydrogen; potassium carbonate; triethylamine; scandium tris(trifluoromethanesulfonate); Raney Ni T-4; In ethanol; dichloromethane;
DOI:10.1055/s-2006-941561

Reference yield:

: dichloro-acetic acid 2-dichloroacetoxy-3-isopropylsulfanyl-1,1-dimethyl-propyl ester

: 908609-70-1
4-(3,3-dimethyl-oxiranylmethyl)-N,N-diethyl-3-hydroxy-5-methoxy-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: SO₂Cl₂; s-collidine / CH₂Cl₂ / 0.2 h / -78 °C

1.2: Et₃N / CH₂Cl₂ / 5 h / -78 - 0 °C

2.1: 98 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: 90 percent / NaBH₄ / CH₂Cl₂ / 2 h / Heating

4.1: 90 percent / H₂ / Raney Ni T-4 / ethanol / 0.5 h / 20 °C

5.1: pyridine / 3 h / 20 °C

6.1: K₂CO₃ / 1 h / 20 °C

7.1: 90 percent / Sc(OTf)3 / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 2,4,6-trimethyl-pyridine; sodium tetrahydroborate; sulfuryl dichloride; hydrogen; potassium carbonate; triethylamine; scandium tris(trifluoromethanesulfonate); Raney Ni T-4; In ethanol; dichloromethane;
DOI:10.1055/s-2006-941561