tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane

Base Information

Chemical Name:tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane
CAS No.:1403676-68-5
Molecular Formula:C₂₀H₃₁FO₄SSi
Molecular Weight:414.614
Hs Code.:

Synonyms:tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane

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Chemical Property of tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane

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Technology Process of tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane

There total 6 articles about tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.9%

: 1403676-74-3
4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohexanone

: 69739-34-0
t-butyldimethylsiyl triflate

: 1403676-68-5
tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Cooling with ice; Inert atmosphere;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1403676-68-5
tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 18 h / Inert atmosphere; Reflux

2.1: lithium borohydride / tetrahydrofuran / 20 h / Inert atmosphere; Reflux

2.2: 0.5 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

5.1: hydrogenchloride / water; tetrahydrofuran / 42 h / 50 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Cooling with ice; Inert atmosphere

With hydrogenchloride; lithium borohydride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 23521-81-5,17159-82-9
(1,4-dioxaspiro[4.5]dec-8-yl)methanol

: 1403676-68-5
tert-butyl(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)cyclohex-1-enyloxy)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

3: hydrogenchloride / water; tetrahydrofuran / 42 h / 50 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Cooling with ice; Inert atmosphere

With hydrogenchloride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;