2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester
CAS No.:1055303-88-2
Molecular Formula:C₂₉H₂₈Cl₃FO₆S₃
Molecular Weight:694.093
Hs Code.:

2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester

Synonyms:2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of 2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

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Technology Process of 2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester

There total 11 articles about 2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid chloride

: 74447-36-2
1-(Methylsulfonyloxy)-2-[4-(methylsulfonyloxy)phenyl]ethane

: 1055303-88-2
2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1055303-64-4
2-(4-fluorophenyl)ethane-1-thiol

: 1055303-88-2
2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 18 h / 0 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 29 h / 0 - 20 °C

2.2: pH 2

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C

5.1: potassium permanganate / acetone / 18 h

6.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

7.1: dmap / dichloromethane / 18 h / 20 °C

With dmap; sodium hydroxide; potassium permanganate; oxalyl dichloride; boron trifluoride diethyl etherate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1055303-67-7
2-chloro-3-(4-hydroxymethyl-phenyl)-propionic acid methyl ester

: 1055303-88-2
2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethylsulfanylcarbonyl]-phenyl}-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / dichloromethane / 17 h / 0 - 2 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 18 h / 0 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 29 h / 0 - 20 °C

3.2: pH 2

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

5.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C

6.1: potassium permanganate / acetone / 18 h

7.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

8.1: dmap / dichloromethane / 18 h / 20 °C

With 1H-imidazole; dmap; sodium hydroxide; potassium permanganate; oxalyl dichloride; boron trifluoride diethyl etherate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;