(4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide

Base Information

Chemical Name:(4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide
CAS No.:99943-75-6
Molecular Formula:C₁₉H₂₀N₂O₃
Molecular Weight:324.379
Hs Code.:

Synonyms:(4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide

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Chemical Property of (4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide

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Technology Process of (4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide

There total 5 articles about (4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2749-94-2
1-methoxy-4-(prop-1-yn-1-yl)benzene

: 99943-75-6
(4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Lindlar catalyst / dioxane

2: triethylamine / ethanol / 48 h

3: 32 percent / H₂O / 14 h / 120 °C

4: 1.) 1M BBr₃ 2.) 10percent KOH / 1.) CH₂Cl₂, 12 h, 20 deg C 2.) 90 min, 20 deg C

With potassium hydroxide; water; hydrogen; boron tribromide; triethylamine; Lindlar's catalyst; In 1,4-dioxane; ethanol;
DOI:10.1002/jlac.198519851107

Reference yield:

: 25679-28-1,25086-72-0,63589-56-0
cis-Anethole

: 99943-75-6
(4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 48 h

2: 32 percent / H₂O / 14 h / 120 °C

3: 1.) 1M BBr₃ 2.) 10percent KOH / 1.) CH₂Cl₂, 12 h, 20 deg C 2.) 90 min, 20 deg C

With potassium hydroxide; water; boron tribromide; triethylamine; In ethanol;
DOI:10.1002/jlac.198519851107

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 99943-75-6
(4R,5R)-4,5-Dihydro-5-(4-hydroxyphenyl)-4-methyl-N-<(S)-1-phenylethyl>-3-isoxazolcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / H₂O / 14 h / 120 °C

2: 1.) 1M BBr₃ 2.) 10percent KOH / 1.) CH₂Cl₂, 12 h, 20 deg C 2.) 90 min, 20 deg C

With potassium hydroxide; water; boron tribromide;
DOI:10.1002/jlac.198519851107