8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]

Base Information

Chemical Name:8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]
CAS No.:1380089-04-2
Molecular Formula:C₂₀H₁₄ClFN₂O
Molecular Weight:352.795
Hs Code.:

Synonyms:8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]

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Chemical Property of 8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]

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Technology Process of 8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]

There total 6 articles about 8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1380090-19-6
6,8-dichloro-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]

: 1765-93-1
4-fluoroboronic acid

: 1380089-04-2
8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 82 ℃; for 0.25h; Inert atmosphere;

Reference yield:

: 1380090-11-8
tert-butyl (1-(3-methyl-4-(4,4,5,5-tetramethyl1,3,2-dioxaborolan-2-yl)isoxazol-5-yl)cyclopropyl)carbamate

: 1380089-04-2
8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]

Guidance literature:: Multi-step reaction with 5 steps

1: potassium dihydrogenphosphate / 1,4-dioxane; methanol / 4 h / 80 °C / Inert atmosphere; Sealed vial

2: hydrogenchloride / methanol / 6 h / 20 °C

3: isopropylmagnesium bromide / hydrogenchloride / 0.25 h / 20 °C

4: phosphorus pentachloride / dichloromethane; chloroform / 0.5 h / 20 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.25 h / 82 °C / Inert atmosphere

With hydrogenchloride; potassium dihydrogenphosphate; phosphorus pentachloride; isopropylmagnesium bromide; sodium carbonate; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; chloroform; toluene;

Reference yield:

: 1380090-13-0
methyl 2-(5-(1-((tert-butoxycarbonyl)amino)cyclopropyl)-3-methylisoxazol-4-yl)-5-chlorobenzoate

: 1380089-04-2
8-chloro-6-(4-fluorophenyl)-1-methylspiro[benzo[c]isoxazolo[4,5-e]azepine-4,1'-cyclopropane]

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol / 6 h / 20 °C

2: isopropylmagnesium bromide / hydrogenchloride / 0.25 h / 20 °C

3: phosphorus pentachloride / dichloromethane; chloroform / 0.5 h / 20 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.25 h / 82 °C / Inert atmosphere

With hydrogenchloride; phosphorus pentachloride; isopropylmagnesium bromide; sodium carbonate; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; chloroform; toluene;