(R)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide

Base Information

• Chemical Name: (R)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide
• CAS No.: 1223578-76-4
• Molecular Formula: C₁₈H₁₇ClF₃NO₂
• Molecular Weight: 371.787

Synonyms:(R)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide

Chemical Property of (R)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide

Chemical Property:

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Technology Process of (R)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide

There total 1 articles about (R)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-(2-chlorophenyl)propanoic acid (1643-28-3) + (R)-2,2,2-trifluoro-1-(3-methoxyphenyl)ethylamine (1213162-90-3,856758-72-0) → (R)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide (1223578-76-4)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1002/ejoc.200901158

Reference yield: 66.0%

(R)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide (1223578-76-4) → (R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-3-(2-chlorophenyl)-1-propylamine (1223578-78-6)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; Inert atmosphere;

DOI:10.1002/ejoc.200901158

upstream raw materials:

3-(2-chlorophenyl)propanoic acid

(R)-2,2,2-trifluoro-1-(3-methoxyphenyl)ethylamine

Downstream raw materials:

(R)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-3-(2-chlorophenyl)-1-propylamine

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