(+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane

Base Information

Chemical Name:(+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane
CAS No.:911298-11-8
Molecular Formula:C₁₇H₂₀F₃NO₄
Molecular Weight:359.345
Hs Code.:

Synonyms:(+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane

Suppliers and Price of (+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane

There total 2 articles about (+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 863982-49-4
(+/-)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane

: 501-53-1,94274-21-2
benzyl chloroformate

: 911298-11-8
(+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane

Guidance literature:: With sodium carbonate; In dichloromethane; water; at 20 ℃;
DOI:10.1002/ejoc.200600157

Reference yield:

: 218602-40-5
2-(2-Methyl-[1,3]dioxan-2-yl)-ethylamine

: 911298-11-8
(+/-)-N-(benzyloxycarbonyl)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 2 steps

1.1: MgSO₄; p-TsOH / CH₂Cl₂ / 4 h / Heating

1.2: 49 percent / p-TsOH / toluene / 1.5 h / 80 °C

2.1: 95 percent / sodium carbonate / CH₂Cl₂; H₂O / 20 °C

With sodium carbonate; magnesium sulfate; toluene-4-sulfonic acid; In dichloromethane; water; 1.2: intramolecular Mannich-type cyclization;
DOI:10.1002/ejoc.200600157