4-(benzylamino)-6-({4-[4-(pyrimidin-2-yl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

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Chemical Name:4-(benzylamino)-6-({4-[4-(pyrimidin-2-yl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide
CAS No.:1227864-85-8
Molecular Formula:C₂₇H₂₈N₈O
Molecular Weight:480.572
Hs Code.:

Synonyms:4-(benzylamino)-6-({4-[4-(pyrimidin-2-yl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

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Chemical Property of 4-(benzylamino)-6-({4-[4-(pyrimidin-2-yl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

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Technology Process of 4-(benzylamino)-6-({4-[4-(pyrimidin-2-yl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

There total 2 articles about 4-(benzylamino)-6-({4-[4-(pyrimidin-2-yl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1227864-55-2
4-(benzylamino)-6-({[4-piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

: 1227864-85-8
4-(benzylamino)-6-({4-[4-(pyrimidin-2-yl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; at 80 ℃; for 6h;

Reference yield:

: 1227864-42-7
4-(benzylamino)-6-({4-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

: 1227864-85-8
4-(benzylamino)-6-({4-[4-(pyrimidin-2-yl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; barium(II) hydroxide / methanol / 0.5 h / 50 °C

2: N-ethyl-N,N-diisopropylamine / ethanol; tetrahydrofuran / 6 h / 80 °C

With water; N-ethyl-N,N-diisopropylamine; barium(II) hydroxide; In tetrahydrofuran; methanol; ethanol;