4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid

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Chemical Name:4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid
CAS No.:169134-91-2
Molecular Formula:C₂₅H₃₁N₅O₅
Molecular Weight:481.552
Hs Code.:

Synonyms:4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid

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Chemical Property of 4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid

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Technology Process of 4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid

There total 13 articles about 4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 169134-90-1
tert-Butyl 4-<3-<2-<<(N,N-dimethylamino)methylene>amino>-3-<(pivaloyloxy)methyl>-4(3H)-oxo-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoate

: 169134-91-2
4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;
DOI:10.1021/jo00129a040

Reference yield:

: 619-58-9
4-iodobenzoic acid

: 169134-91-2
4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / H₂SO₄ / CH₂Cl₂ / 72 h / Ambient temperature

2: 62 percent / CuI, NEt₃ / Pd(PPh₃)4 / CH₂Cl₂ / 0.08 h / Heating

3: 93 percent / H₂ / 10percent Pd/C / methanol / 4 h / 2585.7 Torr

4: 97 percent / Et₃N

5: 95 percent / NaI / acetone

6: 78 percent / NaH / dimethylformamide / 1.) r.t., 2 h, 2.) r.t., 2 h

7: 95 percent / TFA / CH₂Cl₂ / 2 h

With copper(l) iodide; sulfuric acid; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; sodium iodide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00129a040

Reference yield:

: 120363-13-5
tert-butyl 4-iodobenzoate

: 169134-91-2
4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / CuI, NEt₃ / Pd(PPh₃)4 / CH₂Cl₂ / 0.08 h / Heating

2: 93 percent / H₂ / 10percent Pd/C / methanol / 4 h / 2585.7 Torr

3: 97 percent / Et₃N

4: 95 percent / NaI / acetone

5: 78 percent / NaH / dimethylformamide / 1.) r.t., 2 h, 2.) r.t., 2 h

6: 95 percent / TFA / CH₂Cl₂ / 2 h

With copper(l) iodide; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; sodium iodide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00129a040