1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate

Base Information

Chemical Name:1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate
CAS No.:219834-98-7
Molecular Formula:C₁₉H₁₅F₃N₂O₃S
Molecular Weight:408.401
Hs Code.:

Synonyms:1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate

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Chemical Property of 1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate

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Technology Process of 1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate

There total 1 articles about 1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23596-28-3
2,3-dihydro-1H-pyrrolo[3,2-c]pyridine

: 219834-98-7
1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.75 g / CH₂Cl₂ / 3 h / 20 °C

2: 11.0 g / diisobutylaluminum hydride / CH₂Cl₂ / 20 h / Heating

3: 81 percent / N-bromosuccinimide / dimethylformamide / 1.5 h / 0 °C

4: 69 percent / Na₂CO₃; Pd(PPh₃)4 / toluene; ethanol; H₂O / Heating

5: 35 percent / EtSH; AlCl₃

6: 1.90 g / pyridine / 1.17 h / 0 °C

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; diisobutylaluminium hydride; sodium carbonate; ethanethiol; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Acylation / 2: Reduction / 3: Bromination / 4: Arylation / 5: Hydrolysis / 6: Esterification;
DOI:10.1021/jo991011h

Reference yield: 85.0%

: phenylmagnesium bromide

: 219834-98-7
1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate

: (+/-)-1-methyl-7-(2-phenylnaphthyl)-2-pyrrolino[3,2-c]pyridine

Guidance literature:: With bis(diphenylphosphino)propanepalladium(II) dichloride; In diethyl ether; for 24h; Heating;
DOI:10.1021/jo991011h

Reference yield: 53.0%

: 219834-98-7
1-(1-methyl-2-pyrrolino[2,3-d]pyridin-7-yl)-2-naphthyl (trifluoromethyl)sulfonate

: 98-80-6
phenylboronic acid

: (+/-)-1-methyl-7-(2-phenylnaphthyl)-2-pyrrolino[3,2-c]pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; for 18h; Heating;
DOI:10.1016/S0040-4039(98)01951-0