7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene

Base Information

• Chemical Name: 7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene
• CAS No.: 756844-33-4
• Molecular Formula: C₂₇H₃₄O₂S
• Molecular Weight: 422.632
• Mol file: 756844-33-4.mol

Synonyms:7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene

Chemical Property of 7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene

There total 5 articles about 7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene-6-one (756844-31-2) → 7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene (756844-33-4)

Guidance literature:

With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmc.2004.06.017

Reference yield:

(8R,9S,13S,14S,17S)-3,17-dimethoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene (4954-14-7) → 7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene (756844-33-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: t-BuOK; diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.33 h / -15 °C

1.2: 80 percent / trimethylborate; H₂O₂ / H₂O; tetrahydrofuran; hexane / 1 h / 20 °C

2.1: 100 percent / PCC / CH₂Cl₂ / 1 h / 20 °C

3.1: 100 percent / bromine / CH₂Cl₂; CCl₄

4.1: 90 percent / NaOH; tetrabutylammonium hydrogensulfate / H₂O; benzene / 2 h / 20 °C

5.1: 82 percent / boron trifluoride etherate; triethylsilane / CH₂Cl₂ / 0 °C

With triethylsilane; sodium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; potassium tert-butylate; bromine; tetra(n-butyl)ammonium hydrogensulfate; diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; water; benzene;

DOI:10.1016/j.bmc.2004.06.017

Reference yield:

3,17β-bis(methoxy)estra-1,3,5(10)-triene-6-one (238423-12-6) → 7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene (756844-33-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / bromine / CH₂Cl₂; CCl₄

2: 90 percent / NaOH; tetrabutylammonium hydrogensulfate / H₂O; benzene / 2 h / 20 °C

3: 82 percent / boron trifluoride etherate; triethylsilane / CH₂Cl₂ / 0 °C

With triethylsilane; sodium hydroxide; boron trifluoride diethyl etherate; bromine; tetra(n-butyl)ammonium hydrogensulfate; In tetrachloromethane; dichloromethane; water; benzene;

DOI:10.1016/j.bmc.2004.06.017

upstream raw materials:

7α-benzylthio-3,17β-bis(methoxy)estra-1,3,5(10)-triene-6-one

(8R,9S,13S,14S,17S)-3,17-dimethoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

3,17β-bis(methoxy)estra-1,3,5(10)-triene-6-ol

3,17β-bis(methoxy)estra-1,3,5(10)-triene-6-one