1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate

Base Information

Chemical Name:1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate
CAS No.:1359955-74-0
Molecular Formula:C₂₃H₂₇N₃O₄
Molecular Weight:409.485
Hs Code.:

Synonyms:1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate

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Chemical Property of 1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate

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Technology Process of 1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate

There total 5 articles about 1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1359955-68-2
1-benzyloxycarbonyl-4-dimethylamino-2-phenyl-1,3-diaza-1,3-butadiene

: 140-88-5,9003-32-1
ethyl acrylate

: 1359955-84-2
1-benzyl 5-ethyl 2-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate

: 1359955-74-0
1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate

Guidance literature:: In 1,3,5-trimethyl-benzene; at 100 ℃; for 13h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.12.111

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1359955-74-0
1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran; water / 1 h / 0 °C

2: tetrahydrofuran / 5 h / Reflux; Inert atmosphere

3: 1,3,5-trimethyl-benzene / 13 h / 100 °C / Inert atmosphere

With sodium hydroxide; In tetrahydrofuran; water; 1,3,5-trimethyl-benzene;
DOI:10.1016/j.tetlet.2011.12.111

Reference yield:

: 1670-14-0
benzamidine monohydrochloride

: 1359955-74-0
1-benzyl 5-ethyl 4-dimethylamino-2-phenyl-1,4,5,6-tetrahydropyrimidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 0 °C

1.2: 1 h / 0 °C

2.1: tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: 1,3,5-trimethyl-benzene / 24 h / 100 °C / Inert atmosphere

With sodium hydroxide; In tetrahydrofuran; water; 1,3,5-trimethyl-benzene;
DOI:10.1016/j.tet.2012.02.064