Technology Process of 1-((2S,4S)-2-(hydroxymethyl)-4-(3-phenylpropoxy)-pyrrolidine-1-yl)-diphenylethanolate
There total 12 articles about 1-((2S,4S)-2-(hydroxymethyl)-4-(3-phenylpropoxy)-pyrrolidine-1-yl)-diphenylethanolate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,4S)-1-(2,2-diphenylacetyl)-4-(3-phenylpropoxy)pyrrolidine carboxylic acid;
With
borane-THF;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
With
methanol;
In
tetrahydrofuran;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / methanol / 1 h / 20 °C
2.1: silver(l) oxide / dichloromethane / 0 - 20 °C
3.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 0.5 h / 0 °C
3.2: pH 7
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 760.05 Torr
5.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere
5.2: 0 °C
With
borane-THF; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; silver(l) oxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: silver(l) oxide / dichloromethane / 0 - 20 °C
2.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 0.5 h / 0 °C
2.2: pH 7
3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 760.05 Torr
4.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere
4.2: 0 °C
With
borane-THF; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; silver(l) oxide;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate;
