p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate

Base Information

Chemical Name:p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate
CAS No.:85579-94-8
Molecular Formula:C₃₉H₂₉N₅O₁₆S
Molecular Weight:855.749
Hs Code.:

Synonyms:p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate

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Chemical Property of p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate

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Technology Process of p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate

There total 1 articles about p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85579-93-7
2-{(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-1-[(R)-2-methyl-1-(4-nitro-benzyloxycarbonyl)-allyl]-4-oxo-azetidin-2-ylsulfanyl}-malonic acid bis-(4-nitro-benzyl) ester

: 85579-94-8
p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate

Guidance literature:: With dimethylsulfide; ozone; Yield given. Multistep reaction; 1.) methylene dichloride, -78 deg C, 2.) methylene dichloride, RT, 12 h;

Reference yield: 27.6%

: 85579-94-8
p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate

: 85597-67-7
p-nitrobenzyl 2-chloro-2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>acetoacetate

: 85579-95-9
p-nitrobenzyl 2-chloro-1-<(3R,4R)-4--2-oxo-3-phthalimide-4-azetidinyl>acetoacetate

Guidance literature:: With N-chloro-succinimide; In dichloromethane; at -78 ℃; for 1.5h;

Reference yield:

: 85579-94-8
p-nitrobenzyl 2-<(3R,4R)-4-bis(p-nitrobenzyloxycarbonyl)methylthio-2-oxo-3-phthalimido-1-azetidinyl>-3-hydroxycrotonate

: 85579-96-0
p-nitrobenzyl (5R,6R)-3-acetyl-2-bis(p-nitrobenzyloxycarbonyl)-6-phthalimidylpenam-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 41.6 percent / N-chlorosuccinimide / CH₂Cl₂ / 1.5 h / -78 °C

2: 66 percent / potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / -15 - -10 °C

With N-chloro-succinimide; potassium tert-butylate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;