(2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine
CAS No.:203245-67-4
Molecular Formula:C₁₈H₂₅NOS
Molecular Weight:303.469
Hs Code.:

Synonyms:(2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

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Chemical Property of (2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

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Technology Process of (2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

There total 6 articles about (2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 368-39-8
triethyloxonium fluoroborate

: 203245-66-3
(2R,3S,8aR)-8a-Ethyl-3-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-thione

: 203245-67-4
(2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

Guidance literature:: In dichloromethane; for 1h; Heating;
DOI:10.1021/jo9719214

Reference yield:

: 3637-13-6
5-oxoheptanoic acid

: 203245-67-4
(2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / toluene / 12 h / Heating

2: 84 percent / Belleau reagent / toluene / 1 h / Heating

3: 100 percent / CH₂Cl₂ / 1 h / Heating

With 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; In dichloromethane; toluene;
DOI:10.1021/jo9719214

Reference yield:

: 1501-26-4
methyl 4-(chlorocarbonyl)butyrate

: 203245-67-4
(2R,3S,8aR)-8a-Ethyl-5-ethylsulfanyl-3-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / tetrahydrofuran / -78 - 20 °C

2: 92 percent / KOH / H₂O; methanol / 4 h / Ambient temperature

3: 64 percent / toluene / 12 h / Heating

4: 84 percent / Belleau reagent / toluene / 1 h / Heating

5: 100 percent / CH₂Cl₂ / 1 h / Heating

With potassium hydroxide; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/jo9719214