benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate

Base Information

Chemical Name:benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate
CAS No.:1261253-81-9
Molecular Formula:C₁₉H₂₆N₂O₄
Molecular Weight:346.426
Hs Code.:

Synonyms:benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate

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Chemical Property of benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate

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Technology Process of benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate

There total 6 articles about benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.3%

: 110-91-8,99108-56-2
morpholine

(1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid: 1017279-76-3
(1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid

: 1261253-81-9
benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 80-57-9,1196-01-6
(-)-Verbenone

: 1261253-81-9
benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium periodate; water / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C

2.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 °C

2.2: 1.5 h / 0 - 20 °C

3.1: toluene / 4 h / 20 °C / Reflux

4.1: water; sodium hypobromide / 1,4-dioxane / 5 h / -5 °C

4.2: pH 2 - 3

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

5.2: 8 h / 20 °C

With sodium periodate; sodium hypobromide; water; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; ruthenium(III) trichloride hydrate; In 1,4-dioxane; tetrachloromethane; dichloromethane; acetone; toluene; acetonitrile; 3.1: Curtius Rearrangement;

Reference yield:

: 288848-24-8
(1S,3R)-3-acetyl-2,2-dimethylcyclobutane carboxylic acid

: 1261253-81-9
benzyl ((1S,3R)-2,2-dimethyl-3-(morpholin-4-carbonyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 °C

1.2: 1.5 h / 0 - 20 °C

2.1: toluene / 4 h / 20 °C / Reflux

3.1: water; sodium hypobromide / 1,4-dioxane / 5 h / -5 °C

3.2: pH 2 - 3

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

4.2: 8 h / 20 °C

With sodium hypobromide; water; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; acetone; toluene; 2.1: Curtius Rearrangement;