1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

Base Information

Chemical Name:1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil
CAS No.:133272-33-0
Molecular Formula:C₂₁H₂₇N₂O₈P
Molecular Weight:466.428
Hs Code.:

Synonyms:1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

Suppliers and Price of 1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

Chemical Property:

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Technology Process of 1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

There total 4 articles about 1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 133272-32-9
1-(5-O-benzoyl-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)uracil

: 133272-33-0
1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 70 ℃; for 3h;

Reference yield:

: 31843-77-3
1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-3-O-(diethoxyphosphonomethyl)-β-D-ribofuranose

: 133272-33-0
1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 4 steps

1: SnCl₄ / 1,2-dichloro-ethane / 4 h / Ambient temperature

2: 64 percent / hydrazin hydrate, pyridine / 3 h / Ambient temperature

3: 75 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 2 h / Ambient temperature

4: 85 percent / tributyltin hydride, azobisisobutyronitrile (AIBN) / toluene / 3 h / 70 °C

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tin(IV) chloride; hydrazine hydrate; In dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 133272-31-8
1-(5-O-benzoyl-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

: 133272-33-0
1-(5-O-benzoyl-2,3-didesoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 2 h / Ambient temperature

2: 85 percent / tributyltin hydride, azobisisobutyronitrile (AIBN) / toluene / 3 h / 70 °C

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In dichloromethane; toluene;