Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Name:Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
CAS No.:93695-35-3
Molecular Formula:C₃₆H₃₅F₃N₇O₁₂P
Molecular Weight:845.683
Hs Code.:

Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Synonyms:Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 3 articles about Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 93661-17-7
C₅₆H₅₁F₃N₇O₁₃P

: 93695-35-3
Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: With trichloroacetic acid; In methanol; nitromethane; for 0.05h; Ambient temperature;
DOI:10.1246/cl.1984.1267

Reference yield:

: C₃₉H₃₅F₃N₅O₇P

: 93695-35-3
Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: m-chloroperbenzoic acid / 0.17 h / 0 °C

2: 96 percent / 8-quinolinesulfonyl-3-nitro-1H-1,2,4-triazole (QS-NT) / pyridine / 3 h / Ambient temperature

3: 87 percent / 3 percent Cl₃CCOOH / nitromethane; methanol / 0.05 h / Ambient temperature

With 8-quinolinesulfonyl-3-nitro-1H-1,2,4-triazole (QS-NT); 3-chloro-benzenecarboperoxoic acid; trichloroacetic acid; In pyridine; methanol; nitromethane;
DOI:10.1246/cl.1984.1267

Reference yield:

: Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-ethyl ester; compound with pyridine

: 93695-35-3
Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(2,2,2-trifluoro-ethoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / 8-quinolinesulfonyl-3-nitro-1H-1,2,4-triazole (QS-NT) / pyridine / 3 h / Ambient temperature

2: 87 percent / 3 percent Cl₃CCOOH / nitromethane; methanol / 0.05 h / Ambient temperature

With 8-quinolinesulfonyl-3-nitro-1H-1,2,4-triazole (QS-NT); trichloroacetic acid; In pyridine; methanol; nitromethane;
DOI:10.1246/cl.1984.1267