Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester

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Chemical Name:Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester
CAS No.:184246-44-4
Molecular Formula:C₂₀H₂₃NO₅S
Molecular Weight:389.472
Hs Code.:

Synonyms:Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester

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Chemical Property of Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester

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Technology Process of Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester

There total 17 articles about Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 184246-43-3
4-{(E)-2-[(2S,4S)-4-(4-Methoxy-benzyloxy)-3,4-dihydro-2H-pyran-2-yl]-propenyl}-2-methyl-thiazole

: 184246-44-4
Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester

Guidance literature:: 4-{(E)-2-[(2S,4S)-4-(4-Methoxy-benzyloxy)-3,4-dihydro-2H-pyran-2-yl]-propenyl}-2-methyl-thiazole; With 3,3-dimethyldioxirane; potassium carbonate; In dichloromethane; at 0 ℃;

With sodium periodate; In tetrahydrofuran; water;

Reference yield:

: 4-{(E)-2-[(3S,5S)-5-(4-Methoxy-benzyloxy)-2,7-dioxa-bicyclo[4.1.0]hept-3-yl]-propenyl}-2-methyl-thiazole

: 184246-44-4
Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester

Guidance literature:: With sodium periodate; In tetrahydrofuran; water;
DOI:10.1021/ja971946k

Reference yield:

: 20949-84-2
2-methylthiazole-4-carbaldehyde

: 184246-44-4
Formic acid (1S,3S)-3-(4-methoxy-benzyloxy)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-4-oxo-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 83 percent / benzene / Heating

2: BF₃*OEt₂ / CH₂Cl₂

3: CSA

4: 99 percent / NaBH₄; CeCl₃*7H₂O / methanol / 0 - 20 °C

5: Lipase-30 / 1,2-dimethoxy-ethane / 20 °C

6: K₂CO₃ / methanol / 20 °C

7: NaH / dimethylformamide / 0 - 20 °C

8: 3,3-dimethyldioxirane; K₂CO₃ / CH₂Cl₂ / 0 °C

9: NaIO₄ / H₂O; tetrahydrofuran

With sodium tetrahydroborate; sodium periodate; cerium(III) chloride; Lipase-30; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; 3,3-dimethyldioxirane; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; benzene; 1: Wittig reaction / 2: Cycloaddition / 3: acidolysis / 4: Reduction / 5: transesterification / 6: Deacetylation / 7: Etherification / 8: Epoxidation / 9: Oxidation;
DOI:10.1021/ja971946k