1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-(phenylthio)piperidin-1-ium chloride

Base Information

Chemical Name:1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-(phenylthio)piperidin-1-ium chloride
CAS No.:1408294-07-4
Molecular Formula:C₂₂H₂₇NO₂S*ClH
Molecular Weight:405.989
Hs Code.:

Synonyms:1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-(phenylthio)piperidin-1-ium chloride

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Chemical Property of 1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-(phenylthio)piperidin-1-ium chloride

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Technology Process of 1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-(phenylthio)piperidin-1-ium chloride

There total 2 articles about 1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-(phenylthio)piperidin-1-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 40110-55-2
ethyl 2-(1-benzylpiperidine-4-ylidene)acetate

: 108-98-5
thiophenol

: 1408294-07-4
1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-(phenylthio)piperidin-1-ium chloride

Guidance literature:: thiophenol; With sodium hydride; In N,N-dimethyl-formamide; toluene; at 15 ℃; for 0.5h; Inert atmosphere;

ethyl 2-(1-benzylpiperidine-4-ylidene)acetate; In N,N-dimethyl-formamide; toluene; at 25 - 30 ℃; for 20h; Inert atmosphere;

With hydrogenchloride; In N,N-dimethyl-formamide; toluene; for 0.5h; Inert atmosphere;
DOI:10.1021/op300263w

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1408294-07-4
1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-(phenylthio)piperidin-1-ium chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 40 - 50 °C / Inert atmosphere

1.2: 1 h / 20 - 60 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; toluene / 0.5 h / 15 °C / Inert atmosphere

2.2: 20 h / 25 - 30 °C / Inert atmosphere

2.3: 0.5 h / Inert atmosphere

With potassium tert-butylate; sodium hydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/op300263w