3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Base Information

Chemical Name:3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one
CAS No.:1312938-71-8
Molecular Formula:C₃₁H₃₁N₅O₄
Molecular Weight:537.618
Hs Code.:

Synonyms:3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

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Chemical Property of 3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

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Technology Process of 3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

There total 7 articles about 3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1312938-96-7
C₃₀H₃₃N₅O₃

: 530-62-1
1,1'-carbonyldiimidazole

: 1312938-71-8
3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1312938-93-4
1-(5-ethoxypyrimidin-2-yl)-4-hydroxy-6-methylpyridin-2(1H)-one

: 1312938-71-8
3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium chloride / N,N-dimethyl-formamide / 70 °C

2.1: pyridine / dichloromethane / 2 h / 20 °C

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 1 h / 40 °C

4.2: 16 h / 90 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; hydroxylamine hydrochloride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 39268-74-1
2-amino-5-ethoxypyrimidine

: 1312938-71-8
3-{4'-{[4-butyl-1-(5-ethoxypyrimidin-2-yl)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl]methyl}biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / ethyl acetate; toluene / 24.5 h / 85 °C / Reflux

2.1: sulfuric acid / water / 0.25 h / 150 °C

2.2: pH 8 / Cooling with ice

3.1: lithium chloride / N,N-dimethyl-formamide / 70 °C

4.1: pyridine / dichloromethane / 2 h / 20 °C

5.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride / toluene; tetrahydrofuran / 1.5 h / 0 - 90 °C / Inert atmosphere

6.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 1 h / 40 °C

6.2: 16 h / 90 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; sulfuric acid; hydroxylamine hydrochloride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;