10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin

Base Information

• Chemical Name: 10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin
• CAS No.: 103681-50-1
• Molecular Formula: C₂₆H₂₄N₂O
• Molecular Weight: 380.489
• Mol file: 103681-50-1.mol

Synonyms:10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin

Chemical Property of 10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin

There total 2 articles about 10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-Dimethylamino-1,4-dihydroisochinolin (103681-62-5) + diphenylcyclopropenone (886-38-4) → 10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin (103681-50-1)

Guidance literature:

In 1,2-dimethoxyethane; for 90h; Heating;

DOI:10.1055/s-1985-34144

Reference yield:

1,4-Dihydroisocarbostyril (24331-94-0) → 10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin (103681-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / 1.5 h / 155 °C

2: 69 percent / 1,2-dimethoxy-ethane / 90 h / Heating

In 1,2-dimethoxyethane;

DOI:10.1055/s-1985-34144

Reference yield: 86.0%

10a-Dimethylamino-1,2-diphenyl-3-oxo-10,10a-dihydro-3H,5H-pyrrolo<1,2-b>isochinolin (103681-50-1) → 1,2-Diphenyl-3-oxo-3H,5H-pyrrolo<1,2-b>isochinolin (103681-65-8)

Guidance literature:

With methyl iodide; In acetonitrile; at 70 ℃; for 3h;

DOI:10.1055/s-1985-34144

upstream raw materials:

3-Dimethylamino-1,4-dihydroisochinolin

diphenylcyclopropenone

1,4-Dihydroisocarbostyril

Downstream raw materials:

1,2-Diphenyl-3-oxo-3H,5H-pyrrolo<1,2-b>isochinolin

3,5-Dioxo-1,2-diphenyl-3H,5H-pyrrolo<1,2-b>isochinolin