N¹-(4-oxo-2,5-cyclohexadien-1-ylidene)-N²-(4-methylphenyl)-2,2,2-trifluoroethanimidamide

Base Information

• Chemical Name: N¹-(4-oxo-2,5-cyclohexadien-1-ylidene)-N²-(4-methylphenyl)-2,2,2-trifluoroethanimidamide
• CAS No.: 137927-31-2
• Molecular Formula: C₁₅H₁₁F₃N₂O
• Molecular Weight: 292.26

Synonyms:N¹-(4-oxo-2,5-cyclohexadien-1-ylidene)-N²-(4-methylphenyl)-2,2,2-trifluoroethanimidamide

Chemical Property of N¹-(4-oxo-2,5-cyclohexadien-1-ylidene)-N²-(4-methylphenyl)-2,2,2-trifluoroethanimidamide

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Technology Process of N¹-(4-oxo-2,5-cyclohexadien-1-ylidene)-N²-(4-methylphenyl)-2,2,2-trifluoroethanimidamide

There total 4 articles about N¹-(4-oxo-2,5-cyclohexadien-1-ylidene)-N²-(4-methylphenyl)-2,2,2-trifluoroethanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(4-methoxyphenyl)-N'-(4-methylphenyl)-2,2,2-trifluoroethanimidamide (137927-25-4) → N1-(4-oxo-2,5-cyclohexadien-1-ylidene)-N2-(4-methylphenyl)-2,2,2-trifluoroethanimidamide (137927-31-2)

Guidance literature:

With water; In acetonitrile; at -10 ℃; electrolysis: NaClO₄, glassy carbon anode, platinum foil cathode; 5 mA/cm² for 2.5-3.0 F/mol;

DOI:10.1021/jo00090a017

Reference yield: 99.0%

N'-(4-methoxyphenyl)-N-(4-methylphenyl)-2,2,2-trifluoroethanimidamide (137927-25-4) → N1-(4-oxo-2,5-cyclohexadien-1-ylidene)-N2-(4-methylphenyl)-2,2,2-trifluoroethanimidamide (137927-31-2)

Guidance literature:

With sodium perchlorate; In water; acetonitrile; at -10 ℃; electrolysis: glassy carbon anode, platinum cathode;

DOI:10.1016/S0040-4039(00)79443-3

Reference yield:

N-(4-methoxyphenyl)trifluoroacetimidoyl chloride (75999-66-5) → N1-(4-oxo-2,5-cyclohexadien-1-ylidene)-N2-(4-methylphenyl)-2,2,2-trifluoroethanimidamide (137927-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NaH / tetrahydrofuran / 0.5 h / 68 °C

2: 99 percent / H₂O / acetonitrile / -10 °C / electrolysis: NaClO₄, glassy carbon anode, platinum foil cathode; 5 mA/cm² for 2.5-3.0 F/mol

With water; sodium hydride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo00090a017

upstream raw materials:

N'-(4-methoxyphenyl)-N-(4-methylphenyl)-2,2,2-trifluoroethanimidamide

N-(4-methoxyphenyl)-N'-(4-methylphenyl)-2,2,2-trifluoroethanimidamide

N-(4-methoxyphenyl)trifluoroacetimidoyl chloride

p-toluidine

Downstream raw materials:

1-(4'-methylphenyl)-2-(trifluoromethyl)-6-hydroxybenzimidazole

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