(R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

Base Information

• Chemical Name: (R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione
• CAS No.: 1454272-21-9
• Molecular Formula: C₃₃H₃₁ClF₄N₄O₃
• Molecular Weight: 643.081

Synonyms:(R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

Chemical Property of (R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

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Technology Process of (R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

There total 1 articles about (R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione (1454272-21-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield: 75.0%

(R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione (1454272-21-9) + 4-bromobutanenitrile (5332-06-9) → (R)-4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3 (2H,4H,7H)-yl)-1-phenylethyl)amino)butanenitrile (1454273-50-7)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; at 95 ℃; for 12h;

Reference yield: 64.0%

Ethyl 4-bromobutyrate (2969-81-5) + (R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione (1454272-21-9) → (R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H.4H.7H)-yl)-1-phenylethyl)amino)butanoate (1454273-49-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 55 ℃; for 12h;

Downstream raw materials:

(R)-4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H, 4H, 7H)-yl)-1-phenylethyl)amino)butanoic acid

(R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H_.4H_.7H)-yl)-1-phenylethyl)amino)butanoate

(R)-4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3 (2H,4H,7H)-yl)-1-phenylethyl)amino)butanenitrile

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