(4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester

Base Information

• Chemical Name: (4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester
• CAS No.: 853881-01-3
• Molecular Formula: C₁₃H₂₅NO₄
• Molecular Weight: 259.346
• Mol file: 853881-01-3.mol

Synonyms:(4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester;6-Amino-2,4,6-trideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonic Acid 1,1-Dimethylethyl Ester;

Chemical Property of (4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester

Chemical Property:

• Melting Point: 95.9 °C
• Boiling Point: 323.8 °C at 760 mmHg
• PSA: 70.78000
• Density: 1.001 g/cm³
• LogP: 2.28740

Purity/Quality:

98%Min ^*data from raw suppliers

(4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-aceticAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester is a pharmaceutical compound used for prepatartion of protein kinase inhibitors and their use in the treatment of cancer.

Technology Process of (4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester

There total 1 articles about (4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3R,5S)-6-azido-3,5-O-isopropylidene-3,5-dihydroxyhexanoate (887753-26-6) → tert-butyl (3R,5S)-6-amino-3,5-O-isopropylidene-3,5-dihydroxyhexanoate (853881-01-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2h;

Reference yield:

tert-butyl (3R,5S)-6-amino-3,5-O-isopropylidene-3,5-dihydroxyhexanoate (853881-01-3) + 2,4,6-triphenylpyrylium tetrafluoroborate (448-61-3) → C36H40NO4(1+)*BF4(1-)

Guidance literature:

In ethanol; at 80 - 85 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b04497

upstream raw materials:

tert-butyl (3R,5S)-6-azido-3,5-O-isopropylidene-3,5-dihydroxyhexanoate

Refernces

• 1、 -. "2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors". Page/Page column 24. . Retrieved 2010/11/08.