2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid

Base Information

• Chemical Name: 2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid
• CAS No.: 856422-14-5
• Molecular Formula: C₁₅H₁₇NO₈
• Molecular Weight: 339.302
• Mol file: 856422-14-5.mol

Synonyms:2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid

Chemical Property of 2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid

There total 2 articles about 2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-acetoxy-2,5-dioxo-tetrahydrofuran (24766-96-9) + 1-(Benzyloxycarbonyl)-methylhydroxylamine (58581-52-5) → 2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid (856422-14-5)

Guidance literature:

In dichloromethane; for 16h;

DOI:10.1139/v03-123

Reference yield:

N-benzylideneglycine N-oxide benzyl ester (58581-42-3) → 2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid (856422-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NH₂OH*HCl / ethanol

2: 80 percent / CH₂Cl₂ / 16 h

With hydroxylamine hydrochloride; In ethanol; dichloromethane;

DOI:10.1139/v03-123

Reference yield: 88.0%

2-acetoxy-N-benzyloxycarbonylmethyl-N-hydroxy-succinamic acid (856422-14-5) → 5-acetoxy-tetrahydro-1,2-oxazin-3,6-dione

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1139/v03-123

upstream raw materials:

3-acetoxy-2,5-dioxo-tetrahydrofuran

1-(Benzyloxycarbonyl)-methylhydroxylamine

N-benzylideneglycine N-oxide benzyl ester